Already planned in Cornelio Bentivoglio's projects, as a noble chapel, the initial church was octagonal in plan.
The facade was designed by Giovan Battista Aleotti in 1599 and built in 1600.
The original building - located further east - has been affected by frequent floods of the river Po that seriously compromised its stability. A new one was built between 1653 and 1670. The church interior has a single nave, with six side chapels. The vault was entirely restored between 1914 and 1915, as well as a large part of the Temple.
