The Church of Santa Maria degli Angeli, also known as the Church of the Concezione (Eng. Immaculate Conception), is a Franciscan church in the late Lombard Renaissance style.

Consecrated in 1525 and dedicated to the Virgin of the Angels (Vergine Santissima degli Angeli), the building stood directly on the planned perimeter line of the new town fortifications. For this reason, Duke Ercole II d’Este ordered its demolition in 1552, following a project by architect Terzo Terzi. Terzi himself designed the new church, rebuilt in 1602 along Via Roma. Restored between 1720 and 1723, it was later converted into barracks and a lazzaretto during the Napoleonic era, before finally being reopened for worship in 1823.