The present parish church, dedicated to the Nativity of Virgin Mary, was rebuilt between 1829 and 1837, replacing the former medieval cathedral, once the seat of Brescello’s diocese. Its façade, dominated by a bell tower built in 1896, is adorned with two statues - the Virgin and the town’s patron saint, Genesius - both sculpted by Innocente Franceschini and installed in 1899 on either side of the main front. The tower bell contains a set of five bells. 

The façade, overlooking Piazza Matteotti (Matteotti Square), has recently been repainted, restoring its delicate pale tones. Inside, the church preserves numerous works of artistic value, including an altarpiece by Carlo Zatti, and by a fine series of antique candelabra embellishing each altar. Particularly striking are the solemn gilded wooden baldachin, and, to the right of the high altar, a splendid plaster cast by Carlo Pisi, a sculptor from Brescello, depicting Padre Pio.